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| Paper Type | : | Research Paper |
| Title | : | Vaccines as the Medical Weapon for a Promised Healthy Generation |
| Country | : | India |
| Authors | : | Meera Deshmukh || Pranati Tilak || Sujitha V. K. |
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: | 10.9790/264X-0601020105  |
Abstract: Vaccines are the health promise to the next generation. Immunization is the powerful tool that provides immense health benefits to the individuals by the eradication and protection from several diseases. The neonate health promise begins with the maternal immunization. This immunization strategy is an established strategy for the public health. For e.g., studies show immunization of pregnant mother with influenza vaccine decreased the infant infection up to the 6 months of age by 63%. Vaccine efficacy should consider the health and non-health benefits of the individuals of both vaccinated and unvaccinated population. This vigilance helps to know the efficacy of the vaccine in the individuals, effectiveness in the communities and further the impact in the society. The source from which vaccine develops also have impact on the society. For eg:, the administration of vaccine developed from Fetal cell line puts a negative impact to certain societies. Vaccination has significant role in the creation of a healthy population and hence a healthy and prosper nation
[1]. Anekwe, T.D., Newell, M.L., Tanser, F., Pillay, D. and Bärnighausen, T., 2015. The causal effect of childhood measles vaccination on educational attainment: A mother fixed-effects study in rural South Africa. Vaccine, 33(38), pp.5020-5026.
[2]. Bonanni, P., Breuer, J., Gershon, A., Gershon, M., Hryniewicz, W., Papaevangelou, V., Rentier, B., Rümke, H., Sadzot-Delvaux, C., Senterre, J. and Weil-Olivier, C., 2009. Varicella vaccination in Europe–taking the practical approach. BMC medicine, 7(1), p.26.
[3]. Bonhoeffer, J., Kochhar, S., Hirschfeld, S., Heath, P.T., Jones, C.E., Bauwens, J., Honrado, Á., Heininger, U., Muñoz, F.M., Eckert, L. and Steinhoff, M., 2016. Global alignment of immunization safety assessment in pregnancy–The GAIA project. Vaccine, 34(49), pp.5993-5997.
[4]. Bonhoeffer, J., Kochhar, S., Hirschfeld, S., Heath, P.T., Jones, C.E., Bauwens, J., Honrado, Á., Heininger, U., Muñoz, F.M., Eckert, L. and Steinhoff, M., 2016. Global alignment of immunization safety assessment in pregnancy–The GAIA project. Vaccine, 34(49), pp.5993-5997.
[5]. Boonstra, H.D., 2016. Fetal tissue research: A weapon and a casualty in the war against abortion. Guttmacher Policy Review, 19(1), pp.9-15..
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| Paper Type | : | Research Paper |
| Title | : | Bacteria With Heavy Metal Bioremediation Potential Isolated From The Polluted River Water Of Bangladesh |
| Country | : | Bangladesh |
| Authors | : | Sanjeeda Haider Nupur || Abu Rayhan || Sangita Ahmed |
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: | 10.9790/264X-0601020614 |
Abstract: Background: With the increased urbanization and industrial development, the rivers surrounding Dhaka city are getting highly polluted due to discharge of municipal and untreated industrial waste waters which are overloaded with different types of toxic heavy metals including chromium, cadmium, lead, copper, arsenic, nickel etc, which imposes great threat to public health. This study aimed to isolate bacteria with heavy metal bioremediation ability that could be used to remove the toxic heavy metals from water bodies. Method: Bacteria were isolated from water sample collected from the Buriganga river and were identified by using morphological, cultural, biochemical tests and 16s rDNA sequencing. Chromium reduction was investigated by DPC method (Ilias et al., 2011). Results: Two bacteria were isolated and were identified as Proteus mirabilis strain ALK428 and Pseudomonas aeruginosa strain Pse12. Both isolates could tolerateupto500ppm of lead, chromium, cadmium, aluminum, arsenic, zinc and copper. The whole cell of Proteus mirabilis strain ALK428 reduced 38.6%, 27.7%, 13.6% and 7.7% hexavalent chromium when.......
Key words: heavy metal, bioremediation, tolerance, chromium reduction
[1]. Abimbola OA, Olawale OA, Anthony IO, Obasola EF (2019) Metal-resistance encoding gene-fingerprints in some bacteria isolated from wastewaters of selected printeries in Ibadan, South-western Nigeria. J TaibahUniv Sci. 13(1):266–273.
[2]. Ahmad MK, Islam S, Rahman S, Haque MR, Islam MM (2010). Heavy metals in water, sediment and some fishes of buriganga river, Bangladesh. Int J Environ Res 4:321-332.
[3]. Ahmed M, Matsumoto M, Kurosawa K (2018) Heavy Metal Contamination of Irrigation Water, Soil, and Vegetables in a Multi-industry District of Bangladesh. Int J Environ Res12:531–542.
[4]. Barakat MA (2011) New trends in removing heavy metals from industrial wastewater. Arab J Chem 4: 361–377. [5]. Dey S, Paul AK (2013) Hexavalent chromium reduction by aerobic heterotrophic bacteria indigenous to chromite mine overburden. Braz J Microbiol 44(1):307-315.
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| Paper Type | : | Research Paper |
| Title | : | CAR-TCell Therapy: An Innovative Treatment Against Cancer |
| Country | : | |
| Authors | : | Sebastián Arguedas Chacón || Raquel Arguedas Herrera || Daniela González Rodríguez || Dayana Fuentes Herrera || Mariana Murillo Chinchilla || Juan José Mora Román |
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: | 10.9790/264X-0601021525 |
Abstract: Cancer is characterized by uncontrolled growth, along with a spread of abnormal cells. The condition can be caused by various external and internal risk factors.Due to its high mortality rate, ways to treat it have been studied. Traditionally, the therapeutic triad has been used: surgery, radiotherapy, and chemotherapy. However, it generates a number of adverse effects on patients. Because of this, different methods and techniques have been investigated through which it can be attacked more effectively. Among these is the immunotherapy, a stimulation of the patient's immune system to fight cancer cells. T-cell therapy associated with a chimeric antigen receptor (CAR) is a powerful new option for cancer treatment. Patients who have been given this therapy have responded positively, indicating great effectiveness. There are evidences in both children and adults. However, scientists are working on the improvement of aspects such as adverse effects and an extension of the diseases for which the treatment can be used.
Key words: CAR-T cells; immune system; cancer; antibody; immunotherapy
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[2]. National Cancer Institute. Types of cancer[Internet]. Maryland: National Cancer Institute; 2019 [updated 2019 Feb 21; cited 2019 May 28]. Available from: https://www.who.int/en/news-room/fact-sheets/detail/cancer
[3]. American Cancer Society. Datos y Estadísticas sobre el Cáncer entre los Hispanos/Lations 2018-2020. Atlanta: American Cancer Society; 2018. 51 p.
[4]. National Cancer Institute. Risk Factors for Cancer [Internet]. Maryland: National Cancer Institute; 2015 [updated 2015 Dec 23; cited 2019 May 28]. Available from: https://www.cancer.gov/about-cancer/causes-prevention/risk
[5]. DeVita Jr VT, Chu E. A history of Cancer Chemotherapy. Cancer Res. 2008; 68(21):8643-8653..
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| Paper Type | : | Research Paper |
| Title | : | Investigation of Kinetics of Polyphenol Oxidase-Gallic Acid Reaction in Selected Fruits |
| Country | : | Turkey |
| Authors | : | Sibel Yiğitarslan || Ayse Sen |
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: | 10.9790/264X-0601022634 |
Abstract: Enzymatic browning that causes losses in fruits occurs when the enzyme polyphenol oxidase (PPO) (monophenol oxidase E.C.1.14.18.1 or catechol oxidase E.C.1.10.3.1) reacts with oxygen. In this study, the interaction of PPO in red apple, banana and jerusalem artichoke with an antioxidant namely gallic acid was investigated. Gallic acid is presented in well-known database (BRENDA) as a substrate and/or inhibitor of the PPO. In order to investigate the reactions in between different concentrations of gallic acid solution (0-800 μl) with the PPO prepared.....
Key Word:Polyphenol oxidase, Kinetics, Gallic acid, Substrate, Inhibitor
[1]. Elmacı Y, Yılmaz L.Polyphenol oxidase enzyme and inactivation methods. Turkish Journal of Agriculture - Food Science and Technology.2018; 6(3): 333-345. [https://doi.org/10. 24925/turjaf.v6i3.333-345.1727]
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[3]. Cano M, de Ancos B, Lobo M, Santos M. Improvement of frozen banana (Musa cavendishii, cv. Enana) colour by blanching: relationship between browning, phenols and polyphenol oxidase and peroxidase activities. Z Lebensm Unters Forsch. 1997; 204: 60–65. [https://doi.org/10.1007/s002170050038]
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| Paper Type | : | Research Paper |
| Title | : | Plant Cell Culture Systems for the Production of Secondary Metabolites - A Review |
| Country | : | South Africa |
| Authors | : | V. Mohanlall |
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: | 10.9790/264X-0601023547 |
Abstract: Plant cell culture systems represent a potential source of valuable secondarymetabolites which can be used as foodflavourants, colorants, cosmeceuticals, nutraceuticals, and pharmaceuticals. Environmental parameters that effect the cultivation of plants for the production of secondary metabolites include environmentalfactors, political and labour instabilities in the producing countries, uncontrollable variations in the crop quality, cropadulteration, and losses in post-harvest storage and handling. In most cases, the chemicalsynthesis of secondary metabolites is either extremely difficult or not economically feasible. The production of useful and valuable secondary metabolites from cellcultures is an attractive alternative to conventional plant cultivation techniques. Cell culture technology was developed asa possible tool to both study and produce plant secondary metabolites. Theevolving importance of the secondary metabolites.....
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[3]. Ataei-Azimi, A., Hashemloian, B.D., Ebrahimzadeh, H. and Majd, A. (2008) High in vitro production of ant-canceric indole alkaloids from periwinkle (Catharanthus roseus) tissue culture. African Journal of Biotechnology. 7: 2834-2839.
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[5]. Bensaddek, L., Villarreal, M.L. and Fliniaux, M-A. (2008) Induction and growth of hairy roots for the production of medicinal compounds. Electronic Journal of Integrative Biosciences. 3: 2-9.
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| Paper Type | : | Research Paper |
| Title | : | Biochemical Passion Fruit Seeds Characterization (Passifloraedulis F. Flavicarpa Degener) Cultivated In Republic Of The Congo |
| Country | : | Congo |
| Authors | : | J.P.L. Ossoko || Y.Okandza || J. Enzonga Yoca || B. F. Mbete || M.G. Dzondo || M.D. Mvoula Tsieri |
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: | 10.9790/264X-0601024854 |
Abstract: The fruit of the passion (Passi floraedulis f. flavicarpa Degener) native of the Brazil, is a popular fruit in the world. It is a climbing plant, perennial, and Woody that grows everywhere in Republic of Congo. The ripe fruits are harvested and sold in every market in the country. Their seeds are rich in lipids (23,65%). The humidity is 15.18%; Protein, carbohydrates and fiber makers are respectively: 10,53%; 48, 94 and 13,76%. The ash content is 1.70%. Among the identified ions, we got: phosphorus: 0,24%; Iron: 0,01%; Calcium: 0,36% and Magnesium: 0,60%. The energetique calcule value gives a value of 450, 73 Kcal / 100g.
Key Word: Biochemical passion fruit seeds Passifloraedulis f. flavicarpa Degener, characterization.
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[2]. Arts I. C., & Hollman P. C. (2005). Polyphenols and disease risk in epidemiologic studies. TheAmerican Journal of Clinical Nutrition, 81(1): 317–325.
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| Paper Type | : | Research Paper |
| Title | : | Expression of Vitreoscilla Hemoglobin Enhances Glutathione Accumulation in Saccharomyces Cerevisiae |
| Country | : | China |
| Authors | : | Wei Chen || Ning Tian || Tianshun Xu || Mengze Ding || Hui Tang |
|
: | 10.9790/264X-0601025559 |
Abstract: Glutathione (GSH) is an important antioxidant and free radical scavenger in the human body. Maintaining oxygen balance is a major problem in GSH production through fermentation. The study was used to the heterologous expression of vgb, encoding Vitreoscilla hemoglobin (VHb) involved in oxidative metabolic activity, to regulate redox potential in Saccharomyces cerevisiae. Plasmids pYES2-vgb, pYES2-Su9-vgb, and pYES2-vgb-2A-Su9-vgb, which subcellularly localize the expression of VHb in the cytoplasm, mitochondria, and cytoplasm and mitochondria, respectively, were constructed. And GSH production improved 24%, 83%, and 122%, respectively, compared to the parent strain. In this paper, the expression of VHb in the cytoplasm and mitochondria provides a novel approach for the industrial production of GSH by microbial fermentation and a solution for the problem of compromised cell growth and the accumulation of reducing agents during industrial fermentation.
Key Word: Glutathione, Saccharomyces cerevisiae, Vitreoscilla Hemoglobin, Location expression
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